| Publisher | Title | # of Issues |
|---|---|---|
| Devil's Due Publishing | I Am Legion | 2 |
| Fantagraphics | I Before E (1991-1992) | 2 |
| Slave Labor Graphics | I Feel Sick (1999-2000) | 2 |
| Image Comics | Ice Cream Man | 1 |
| BOOM! Studios | In The Blood | 1 |
| Humanoids Publishing | Incal (2001-2002) | 11 |
| Marvel Comics | Incredible Hulk (1968-1999) | 4 |
| Image Comics | Indigo Vertigo | 1 |
| DC Comics/Vertigo Comics | Industrial Gothic | 5 |
| Image Comics/Top Cow Comics | Inferno: Hellbound (2002) | 1 |
| IDW Publishing | Infestation 2: 30 Days of Night | 1 |
| Image Comics | Infinite Horizon (2007-2011) | 3 |
| Image Comics | Inkblot (2020-2022) | 1 |
| Oni Press | Invader Zim (2015-2020) | 5 |
| Image Comics | Iron Ghost | 6 |
